STRUCTURE BASED ANTIBACTERIAL ACTIVITY OF 1,3-DIARYL-2-PROPEN-1-ONES AND THEIR RECENT PHARMACOLOGICAL INTERESTS

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INTRODUCTION

Chalcones are excellent scaffolds not only for synthetic manipulations but also act as a unique template responsible for numerous pharmacological activities1. Biphenylic bridged core structure of chalcone provides firm backbone for generation of potential pharmacophore when derivatized2-3 yields multiple potent and highly selective medicinal active compounds with differential biological activities4-14. Chalcones are the close conger of naturally occurring bioactive flavonoid, isoflavonoids & their analogues but differ from them in having dual (instead of triple) ring system. Xanthohumol, cardamonin, and flavokawains A, B, C are only few bioactive naturally occurring chalcones derivatives that posses potent anticancer, vasorelaxant and anti-inflammatory properties15-17. However, occurs naturally isolation of chalcones employs tedious multi-step time-consuming complicated methodologies which rarely compatible & comparable with end product yield.

Chemistry of Chalcones

Chalcone (1,3-diaryl-2-propen-1-ones) also termed as benzalacetophenone or benzylidene acetophenone was initially named by Kostanecki and Tambor18. These compounds contain two aromatic ring systems A and B linked by highly reactive keto-ethylenic group

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