ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DIFFERENT TRIAZOLE ANALOGUES

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INTRODUCTION

In the previous years the synthesis of high nitrogen containing heterocyclic systems has been attracted to many pharmaceutical and agrochemical industries. The triazole nucleus is one of the most important heterocycles which is a feature of natural products and medicinal agents. Triazole has a five-membered ring of two carbon atoms and three nitrogen atoms.Triazole nucleus is enjoying their importance as being the center of activity. The nitrogen containing heterocyclics are found in abundance in most of the medicinal compounds. The triazoles are said to be the isosters of imidazoles in which the carbon atom of imidazole is isosterically replaced by nitrogen [1-5]. Triazole refers to either one of a pair of isomeric chemical compounds with molecular formula C2H3N3, having a fivemembered ring of two carbon atoms and three nitrogen atoms. The two isomers are:

Out of these two, 1,2,4-triazole possess significant and wide variety of activity in comparison to 1,2,3-triazole [6]. 1,2,3-triazole is considered to be the most stable organic compound in comparison to all other organic compounds possessing three adjacent nitrogen atoms. Aziridine was formed by flash vacuum pyrolysis from 1,2,3-triazole at 500

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